Professor Jacob George is the Robert W. Storr Professor of Hepatic Medicine at the Storr Liver Unit, Westmead Millennium Institute, University of Sydney and is Head of the Department of Gastroenterology and Hepatology at Westmead Hospital and Director of Gastroenterology and Hepatology Services for the Western Sydney Local Health Network.
He undertakes basic and clinical research on hepatitis C, liver cancer, NASH and hepatic fibrosis. He is or was on the Editorial Board of several Journals including Hepatology, Liver international, Hepatology International and the World Journal of Gastroenterology.
Professor George is a member of the Executive Council of the Asian Pacific Association for the Study of the Liver and of the Gastroenterological society of Australia.
The Storr Liver Unit has about 50 students and staff undertaking liver research and management of patients with hepatic disease. Click here for information on the Storr Liver Unit.
Professor George undertakes basic and clinical research on non-alcoholic steatohepatitis (NASH) and hepatic fibrosis.
He is also researching the molecular and cellular basis for disease progression in chronic hepatitis C.
His work on human hepatic cytochrome P450 expression was the first to demonstrate the existence of disease-specific alterations in hepatic drug metabolism in cirrhosis.
In the United States, he published seminal papers on the central role of transforming growth factor beta (TGF beta) in fibrogenesis.
Since returning to Australia, Professor George has worked on fibrosis in NASH, with particular regard to the role of oxidative stress. He has established the Westmead NASH and HCV databases. These cohorts collectively comprise >500 patients and are the subject of multiple publications.
Professor Jacob George's research has been published in many high impact international journals, including Nature Genetics and Hepatology.
Click here for a full listing of Professor George's publications.